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Abstract Detail

Genetics Section

Rogers, Angel [1], Smalls, DeAna [1], Leonard, Victor [1], Ullah, Hemayet [1].

Arabidopsis scaffold protein RACK1A regulates diverse environmental stress signaling pathways.

RACK1 (Receptor for Activated C Kinase 1) is a WD-40 scaffold protein, conserved in eukaryotes. In the model plant Arabidopsis thaliana, the genome maintains three different RACK1 genes termed RACK1A, RACK1B, and RACK1C with a very high (85-93%) sequence conservation. Loss of function mutants in Arabidopsis indicate that RACK1 proteins regulate environmental stress signaling pathways, namely the drought stress resistance pathway. RACK1A- the predominant isoform, is found to interact with diverse environmental stress related proteins. Deduced crystal structure of RACK1A indicates that post-translational modifications like sumoylation and phosphorylation can regulate its function. Tyrosine phosphorylation on residue 248 is found to regulate its homo-dimerization capacity as well as its interactions with other proteins (Kundu et al., 2013). Small compounds inhibiting Y248 phosphorylations are isolated and the effectiveness of the compounds in regulating diverse environmental stress responses by the model plant Arabidopsis are evaluated. Here we present evidence that the compounds are effective in regulating salt and drought stress responses in Arabidopsis.

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1 - Howard University, Biology Department, Washington, DC, 20059, USA

plant stress
plant signaling

Presentation Type: Poster:Posters for Sections
Session: P
Location: Grand Salon A - D/Riverside Hilton
Date: Monday, July 29th, 2013
Time: 5:30 PM
Number: PGN004
Abstract ID:506
Candidate for Awards:None

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